Phenylephrine and promethazine can be taken with or without food. Administration of promethazine HCl has been associated with reported cholestatic jaundice. Once treatment begins, the dose should be reduced to the smallest effective amount needed to control symptoms. Some of these products contain sulfites. Sulfites may cause an allergic reaction in some patients eg, asthma patients. Discuss the risks and benefits with your doctor before breast-feeding.
This information should not be used to decide whether or not to take Phenergan suppositories or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Phenergan suppositories. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Phenergan suppositories. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Phenergan suppositories.
Drowsiness is the most prominent CNS effect of this drug. Sedation, somnolence, blurred vision, dizziness, confusion, disorientation, and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, tremors, convulsive seizures, excitation, catatonic-like states, hysteria. Hallucinations have also been reported. Primary brain tumors are often benign but can cause seizures, ongoing headaches, or loss of coordination. The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your not to work correctly. These are possible, but not always occur. Your doctor or can often prevent or manage interactions by changing how you use your medications or by close monitoring.
If you are over 60 years of age, you may be more likely to experience side effects from phenylephrine and promethazine. Your doctor may prescribe a lower dose of this medication. Sedation in both children and adults, as well as relief of apprehension and production of light sleep from which the patient can be easily aroused. Parenteral formulations of this drug may cause severe chemical irritation and tissue damage regardless of the route.
Some MEDICINES MAY INTERACT with Phenergan suppositories. Barbiturates are substituted pyrimidine derivatives in which the basic structure common to these drugs is barbituric acid, a substance which has no central nervous system CNS activity. CNS activity is obtained by substituting alkyl, alkenyl, or aryl groups on the pyrimidine ring. What Is Ischemic Heart Disease? To relieve dry mouth, suck sugarless hard candy or ice chips, chew sugarless gum, drink water, or use a saliva substitute. Phenergan Promethazine HCl Suppositories should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Do not use Phenergan Injection if solution has developed color or contains precipitate. Phenergan may cause the results of some pregnancy tests to be wrong. Check with your doctor if you have questions or concerns about your pregnancy test results. McGee JL, Alexander MR. Phenothiazine analgesia--fact or fantasy?
When given concomitantly with Phenergan Injection, the dose of barbiturates should be reduced by at least one-half, and the dose of narcotics should be reduced by one-quarter to one-half. Dosage must be individualized. Excessive amounts of Phenergan Injection relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain. Consult your doctor before -feeding. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. If you are using Phenergan for motion sickness, take a dose at least 30 to 60 minutes before you begin traveling. Dupuytren's contracture is a condition of the hand tissue that causes the fingers to curl.
Phenergan suppositories should be used with extreme caution in CHILDREN 2 years old or older. The lowest effective dose should be used in children 2 years old and older. Therapy with phenothiazines should be administered cautiously in patients with preexisting liver disease, liver enzyme abnormalities, or hepatitis. Liver function and urine bilirubin tests should be performed periodically during prolonged therapy, and patients should be instructed to immediately report any signs or symptoms suggestive of cholestatic jaundice such as upper abdominal pain, nausea, yellow skin, influenza-like symptoms, rash, and fever. Phenothiazine therapy should be discontinued, preferably permanently, if jaundice occurs and is attributable to the drug. Clinical recovery is usually observed within a few weeks following withdrawal of therapy, although histopathologic changes may persist for longer periods. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Than she mixed up everything. United States are appropriate, unless specifically indicated otherwise. Patients should be advised of the risk of severe tissue injury, including gangrene see . Patients should be advised to immediately report persistent or worsening pain or burning at the injection site.
Phenergan Injection should be used cautiously in persons with cardiovascular disease or impairment of liver function. Specific studies to test the action of the drug on parturition, lactation, and development of the animal neonate were not done, but a general preliminary study in rats indicated no effect on these parameters. Although antihistamines have been found to produce fetal mortality in rodents, the pharmacological effects of histamine in the rodent do not parallel those in man. There are no adequate and well-controlled studies of Phenergan Promethazine HCl Suppositories in pregnant women. Talk about conspiracy theories. Increased or decreased blood pressure, tachycardia, bradycardia, faintness. In pediatric patients 2 years of age and older, the dosage should not exceed half that of the suggested adult dose.
This medication may interfere with certain laboratory tests including some pregnancy tests, glucose tolerance test, allergy skin testing possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug. Phenothiazines may cause hypotension including orthostatic hypotension reflex tachycardia, increased pulse rate, syncope, and dizziness, particularly after the first parenteral dose but rarely after the first oral dose. Low-potency agents such as chlorpromazine and thioridazine are more likely to induce these effects, which usually subside within the first couple of hours following administration. Tolerance to the hypotensive effects often develops after a few doses. Rarely, fatal cardiac arrest has occurred secondary to severe hypotension. Other reported adverse cardiovascular effects include edema, thrombosis, and ECG abnormalities such as PR and QT interval prolongation, diffuse T-wave flattening, and ST segment depression. Therapy with phenothiazines should be avoided or otherwise administered cautiously in patients with severe cardiovascular disease, pheochromocytoma, a predisposition to hypotension, or conditions that could be exacerbated by hypotension such as a history of myocardial infarction, angina, or ischemic stroke. Close monitoring of cardiovascular status, including ECG changes, is recommended at all dosages. If parenteral therapy is given, patients should be in a supine position during administration and for at least 30 to 60 minutes afterwards. Patients who experience orthostatic hypotension should be cautioned not to rise too abruptly. Occasionally, when severe, hypotension may require treatment with vasoconstrictive agents such as norepinephrine or phenylephrine. Epinephrine should not be used, however, since phenothiazines can reverse its vasopressor effects and cause a further lowering of blood pressure. Medication side effects include nausea, vomiting, stomach upset, weakness, dizziness, seizures, and more. Hyperexcitability and abnormal movements have been reported in patients following a single administration of Phenergan Injection. Consideration should be given to the discontinuation of Phenergan Injection and to the use of other drugs if these reactions occur. Respiratory depression, nightmares, delirium, and agitated behavior have also been reported in some of these patients. Codeine is a narcotic. It is a pain reliever and a cough suppressant. Phenylephrine and promethazine may also be used for purposes other than those listed in this medication guide. Many people using this medication not have serious side effects. See USP Controlled Room Temperature. This is not a complete list of possible side effects. Promethazine hydrochloride is a phenothiazine derivative which possesses antihistaminic, sedative, antimotion-sickness, antiemetic, and anticholinergic effects. Promethazine is a competitive H 1 receptor antagonist, but does not block the release of histamine. Hyperventilation is rapid or shallow breathing usually caused by stress or anxiety.
When someone has a panic attack, that person feels a sudden, intense fear that can't be controlled. Raxar grepafloxacin US prescribing information. Glaxo Wellcome, Inc. Parenteral or rectal formulations may be used when patients cannot tolerate oral formulations. If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. Relation to cigarette smoking, blood pressure, and dosage. National Library of Medicine and National Institutes of Health. The preferred parenteral route of administration for PHENERGAN Injection is by deep intramuscular injection. Parenteral formulations: Store ampoules in the carton until ready to use. Excessively large dosages of antihistamines, including Phenergan Injection, in pediatric patients may cause sudden death see . Hallucinations and convulsions have occurred with therapeutic doses and overdoses of Phenergan Injection in pediatric patients. In pediatric patients who are acutely ill associated with dehydration, there is an increased susceptibility to dystonias with the use of Phenergan Injection.
Check the labels of all your medications to make sure you are not taking more than one product containing guaifenesin or dextromethorphan. It is unknown if promethazine passes into breast milk. It may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding. All medicines may cause side effects, but many people have no, or minor, side effects. She refused to ever go back in her bedroom after that. Than she accused her lovely home nursing aide of threatening her to put her in an institution, than begged me to never do that to her. OMG no-one ever said that to her. Tell your doctor if your condition persists or worsens, or if bleeding from the rectum occurs. If you think you may have a serious medical problem, seek immediate medical attention.
This may not be a complete list of all interactions that may occur. Ask your health care provider if Phenergan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Monitoring your weight: This involves daily recording of weight, increasing your activity level as recommended by your doctor resting between activities more often, and planning your activities. Store at room temperature away from light and moisture. not store in the bathroom. Do not freeze. Keep all away from children and pets. It is possible that the title of this topic is not the name you selected. It is unknown if this medication passes into milk. Rare Disease Database under "Rare Disease Information". For prophylaxis of nausea and vomiting, as during surgery and the postoperative period, the average dose is 25 mg repeated at 4- to 6-hour intervals, as necessary. Marilyn, then Michael Jackson. Celebrities should NOT be allowed to have private house call or live in doctors. BOTH had sleep issues. BOTH MJ at least is verified had their docs kill them. Store this medication at room temperature away from moisture, heat, and light.
Symptoms may include convulsions; dry mouth; flushing; hallucinations; loss of consciousness; nightmares; seizures; shortness of breath; trouble breathing; unusual drowsiness or restlessness. Phenergan suppositories may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Phenergan suppositories with caution. Experts are not sure what causes migraines. Be careful when you use your migraine medicines. Taking them too often can cause you to get another headache when you stop taking the medicine. Strenkoski-Nix LC, Ermer J, DeCleene S, Cevallos W, Mayer PR August 2000. It is possible that the main title of the report is not the name you expected. Please check the listing to find the alternate names and covered by this report.
Symptoms of intoxication include euphoria, slowed reaction time, dizziness, confusion, numbness, and more. Neuroleptic malignant syndrome NMS is a possibly fatal syndrome that can be caused by Phenergan suppositories. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms. Avoid prolonged exposure to sunlight. Phenylephrine and promethazine may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable. Migraines run in families, but it isn't clear why some people get migraines and others don't. Phenergan Promethazine HCl Rectal Suppositories are not recommended for children under 2 years of age. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. You may not be able to use some medicines if you are or have other health problems, such as problems. Amelioration of allergic reactions to blood or plasma. FDA pregnancy category C. This medication may be harmful to an unborn baby. It works by thinning and loosening in the airways, clearing congestion, and making breathing easier. Do not take other over-the-counter cough, cold, allergy, diet, pain, fever, or sleep medicines while taking phenylephrine and promethazine without first talking to your doctor or pharmacist. Other medications may also contain phenylephrine, promethazine or other similar drugs, and you may accidentally take too much, which could be harmful. Since therapeutic requirements for sedative drugs tend to be less in geriatric patients, the dosage should be reduced for these patients. Convulsions may rarely occur. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; blurred vision; burning, pain, swelling, or blistering around the injection site; confusion; excessive sweating; fainting; fever, chills, or persistent sore throat; hallucinations; loss of coordination; mental or mood changes eg, agitation, delirium, exaggerated sense of well-being, excitability, hysteria, nervousness; ringing in the ears; seizures; severe of persistent dizziness; shortness of breath or trouble breathing; slow or fast heartbeat; tremor; trouble sleeping; uncontrolled muscle movements eg, arm or leg movements, twitching of the face or tongue, jerking or twisting; unusual bruising or bleeding; yellowing of the skin or eyes.
Nonteratogenic Effects Phenergan Promethazine HCl Suppositories administered to a pregnant woman within two weeks of delivery may inhibit platelet aggregation in the newborn. This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Avoid alcoholic beverages. The recommended dosage of Noctec brand name of Chloral Hydrate for adults is 500 mg to 1 g, taken ½ hour before surgery, or as directed by your doctor. Noctec may interact with other medications, including oral anticoagulants, IV furosemide, and other CNS depressants. Do not drive, use machinery, or do any activity that requires alertness or clear vision while taking Noctec. Avoid alcoholic beverages. Use this vitamin regularly to get the most benefit from it. To help you remember, take it at the same time each day. Phenergan is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Phenergan at home, a health care provider will teach you how to use it. Be sure you understand how to use Phenergan. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions. What happens if I miss a dose Phenergan Vc? It also has a drying effect. Dispense in well-closed container. Store in the refrigerator. not freeze. Keep all away from children and pets. Phenergan Injection should not be used in pediatric patients less than 2 years of age because of the potential for fatal respiratory depression. Postmarketing cases of respiratory depression, including fatalities, have been reported with use of promethazine in pediatric patients less than 2 years of age. A wide range of weight-based doses of Phenergan Injection have resulted in respiratory depression in these patients. The dosage is based on your age, medical condition, and response to treatment. In children, the dosage may also be based on weight. Do not increase your dose or take this medication more often than directed. Due to the risks of intravenous injection, the preferred route of administration of Phenergan Injection is deep intramuscular injection. Subcutaneous injection is contraindicated. See for important notes on administration. Any of these symptoms of ischemic heart disease warrant immediate medical evaluation.
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B6 in people who not get enough of the vitamin from their diets. Atropine-like signs and symptoms-dry mouth; fixed, dilated pupils; flushing; etc. This medication has been prescribed for your current condition only. Do not use it later for another condition unless told to do so by your doctor. A different medication may be necessary in those cases. God to not be going thru this bk then. I have great docs! If you have any questions about Phenergan suppositories, please talk with your doctor, pharmacist, or other health care provider.
Usual adult dosage is 50 mg promethazine HCl with an appropriately reduced dose of narcotic or barbiturate and the required amount of a belladonna alkaloid. The drug was injected improperly, resulting in and subsequent amputation of her right forearm below the elbow. To ensure that you get a correct dose, measure the liquid form of phenylephrine and promethazine with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.
Don't watch TV or read. Put a cold pack or cool cloth on the painful area. Seek emergency medical attention if an overdose is suspected. What was the connection between all of the above during the sixties and how could it possibly have any bearing now? Phenergan Promethazine HCl Suppositories are contraindicated for use in pediatric patients less than two years of age. The central dopaminergic blocking effects of phenothiazines may precipitate or aggravate a potentially fatal symptom complex known as Neuroleptic Malignant Syndrome NMS. NMS is observed most frequently when high-potency neuroleptic agents like haloperidol or fluphenazine are administered intramuscularly but may occur with any agent possessing neuroleptic activity given for any length of time. Clinical manifestations of NMS include hyperpyrexia, muscle rigidity, altered mental status and autonomic instability irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac arrhythmias. Phenothiazine therapy should not be initiated in patients with active NMS and should be immediately discontinued if currently being administered in such patients. In patients with a history of NMS, introduction or reintroduction of phenothiazines should be carefully considered, since NMS may recur.
The suppository is for rectal use only. The Red Diaries was released as a four-issue series with each issue running 48 pages. Written by Gary Reed, it featured artwork from Chris Jones, Laurence Campbell, Larry Shuput, and Ken Meyer, Jr. In addition to the story line, there is background information that will provide a wider view on the story line. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions.